MEN 11270 - CAS 235082-52-7

Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3) ; conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5) .

Bradykinin Receptor

GPCR/G Protein

235023

C60H90N20O11S

1299.56

O=C1N2[C@@]3([C@](C[C@]2(C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC[C@H](NC([C@H](CC4=CC=CS4)NC(CNC(=O)[C@H]5N(C(=O)[C@H]6N(C([C@@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCC6)C[C@H](O)C5)=O)=O)C(=O)N7[C@@]1(CC=8C(C7)=CC=CC8)[H])[H])(CCCC3)[H])[H]

-20°C

Ice Packs

Peptide