Menin-MLL inhibitor 21 - CAS 2448172-22-1

Menin-mll inhibitor 21 is a selective, oral and irreversible Menin inhibitor. Menin-MLL inhibitor 21 promotes selective proliferation of β cells and improvement of β cell function in human islet cultures in vitro. Menin-MLL inhibitor 21 enhances glycemic control in animal models of diabetes. Menin-MLL inhibitor 21 induced a dose-dependent increase in insulin secretion that was augmented by a GLP-1 receptor agonist (RA) .

Histone Methyltransferase, Epigenetic Reader Domain

Chromatin/Epigenetic

2448149

0.9995

C31H34N8O3

566.65

N(C(=O)C1=CC(CN2C[C@H](NC(C=C)=O)CCC2)=CC=N1)C3=CC=C(C4=CC5=C(N=CN=C5N4)N6CCOCC6)C=C3

-20°C

Ice Packs

Small Compound