Merestinib - CAS 1206799-15-6

Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing the constitutively activated c-Met protein.

ROS, ROS Kinase, FLT, c-Met/HGFR, Discoidin Domain Receptor (DDR)

Angiogenesis, Immunology/Inflammation, Tyrosine Kinase/Adaptors

1206778

0.9971

C30H22F2N6O3

552.53

O(C1=C(C=C2C(=C1)C=NN2C)C=3C=NNC3)C4=C(F)C=C(NC(=O)C=5C(=O)N(C(C)=CC5)C6=CC=C(F)C=C6)C=C4

-20°C

Ice Packs

Small Compound