MerTK/Axl-IN-1 - CAS 3036009-40-9

MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.

TAM Receptor

Tyrosine Kinase/Adaptors

3035960

C40H47FN6O4

694.84

C([C@@H](CO)O)N1CCN([C@@H]2C=3C(=CC(=CC3)C4=CC=C(CO[C@@H]5[C@@H](NC(=O)C=6C=C(C=NC6N)C7=C(F)N=CC=C7)CCC5)C=C4)CCC2)CC1

-20°C

Ice Packs

Small Compound