Mesutoclax - CAS 2760536-87-4

Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM, demonstrating weak activity against BCL-XL (IC50: >1000 nM) . It inhibits the viability of RS4;11 cells with an IC50 of 2.75 nM and can be utilized in cancer research.

Bcl-2 Family

Apoptosis

2760445

C45H50ClN7O8S

884.44

C(C1=C(CC(C)(C)CC1)C2=CC=C(Cl)C=C2)N3[C@H](C)CN(CC3)C4=CC(OC=5C=C6C(=NC5)NC=C6)=C(C(NS(=O)(=O)C7=CC(N(=O)=O)=C(NC[C@H]8COCCO8)C=C7)=O)C=C4

-20°C

Ice Packs

Small Compound