MET Transcription-IN-1 - CAS 3082125-66-1

MET Transcription-IN-1 (Compound C3) is an orally active inhibitor of MET transcription that efficiently binds to and stabilizes the G-quadruplex in the MET promoter region, thereby inhibiting c-Met expression. It can overcome resistance caused by specific c-Met mutations and effectively inhibits tumor cell proliferation, migration, and invasion, inducing cell cycle arrest and apoptosis. This compound exhibits antitumor activity and is applicable in the study of tumors such as non-small cell lung cancer.

Apoptosis, c-Met/HGFR

Tyrosine Kinase/Adaptors, Apoptosis

3082058

C24H16N4O2

392.41

N1=CC=CC=2C1=C3N=CC=CC3=C4NC(=NC24)C=5OC(=CC5)C=6C=CC=C(OC)C6

-20°C

Ice Packs

Small Compound