Methylnissolin - CAS 73340-41-7

Methylnissolin is a natural product isolated from Astragalus membranaceus that inhibits platelet-derived growth factor (PDGF) -BB-induced cell proliferation with an IC50 of 10 μM. It inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibiting the ERK1/2 MAP kinase cascade. It also inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinases and has antibacterial and anticancer effects.

PDGFR, ERK

Tyrosine Kinase/Adaptors, MAPK, Angiogenesis

73292

0.9998

C17H16O5

300.31

[H][C@@]12COc3cc(O)ccc3[C@]1([H])Oc1c2ccc(OC)c1OC

-20°C

Ice Packs

Natural Product