MF-592 - CAS 1064195-48-7

MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM) . In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg/kg/day) .. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further development.

Others, Prostaglandin Receptor

Immunology/Inflammation, GPCR/G Protein, Others

1064140

C34H33Cl2N3O6S

682.61

O(CC)C1=C2C(=C(OCC)C=3C1=CC=CC3)CN(C2=O)C4=C(C)C=C(CC5(NC(NS(=O)(=O)C6=C(Cl)C=CC=C6Cl)=O)CC5)C=C4

-20°C

Ice Packs

Small Compound