MG2N001 - CAS 2760515-88-4

MG2N001, a negative allosteric modulator (NAM) of the metabotropic glutamate receptor mGluR2, has an IC50 of 93 nM and binds to mGluR2 as an antagonist with a Ki of 63 nM. This compound is microparticle- and plasma-stable, and its radioisotope [11C] mG2N001 can be utilized in PET imaging. [11C] mG2N001 exhibits good brain heterogeneity and penetration, selectively accumulating in mGluR2-rich regions to produce high-contrast brain images [1].

Src, GluR

Angiogenesis, Tyrosine Kinase/Adaptors, Neuroscience

2760515-88-4

C18H19FN2O3

330.35

FC1=C(C2=C3C(=NC(C(N)=O)=C2)OC(C)(C)CC3)C=CC(OC)=C1

-20°C

Ice Packs

Small Compound