MGD-28 - CAS 2991818-13-2

MGD-28 is a potent, orally active Cullin-CRBN-dependent IKZF family protein degrader that dose-dependently degrades IKZF1 (Ikaros), IKZF2 (Helios), and IKZF3 (Aiolos) at nanomolar strengths.MGD-28 also degrades CK1α, and has shown antiproliferative activity against a variety of hematologic cancer cell lines showing antiproliferative activity in vitro and antitumor effects in in vivo assays, and is commonly used in multiple myeloma (MM) and hematological disorders.

IKZF, Casein Kinase

Immunology/Inflammation, Stem Cells, Metabolism

2991803

0.9939

C33H34FN7O3

595.67

N#CC1=CC=C(C=C1F)N2CCN(CC3=CC=C(C=C3)CNC4=CC=CC=5C(=O)N(N(C)CC45)C6C(=O)NC(=O)CC6)CC2

-20°C

Ice Packs

Small Compound