MGD-4 - CAS 2991817-99-1

MGD-4 is an orally active, Cereblon (CRBN) -dependent degrader of IKAROS proteins that demonstrates dose-dependent degradation of IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) . The compound effectively inhibits the growth of multiple myeloma.

IKZF, E3 Ligase Ligand-Linker Conjugate

PROTAC, Immunology/Inflammation

2991717

C14H16N4O3

288.3

O=C1C=2C=CC=C(N)C2CN(N1C3C(=O)NC(=O)CC3)C

-20°C

Ice Packs

Small Compound