MI-1063 - CAS 1410737-39-1

MI-1063 is a DMD-2 inhibitor that prevents the MDM2-p53 interaction and activates p53's tumor-suppressing abilities. It inhibits the growth of cancer cells RS4-11 and MV4-11, with IC50 values of 179 nM and 93 nM, respectively. MI-1063 serves as a target protein ligand for the synthesis of the PROTAC degrader [MD-265].

Ligands for Target Protein for PROTAC, MDM-2/p53

PROTAC, Apoptosis

1410697

C30H32Cl2FN3O4

588.5

O=C1[C@@]2(C3(N[C@@H](C(N[C@H]4CC[C@H](C(O)=O)CC4)=O)[C@@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6

-20°C

Ice Packs

PROTAC