MI891 - CAS 2530027-77-9

MI891 is a highly selective PXR antagonist (IC50= 3.76 μM, Kd= 1.7 μM) and inverse agonist (IC50= 6.1 μM) . It selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin-induced PXR activation and can be utilized in research on metabolic and other diseases.

Others, Cytochromes P450

Others, Metabolism

2529941

C23H14Cl2F2N6O

499.3

O=C(N)C1=CC(=CC=C1Cl)CN2N=NC(=C2)C3=C(N=C4C(F)=CC(F)=CN43)C=5C=CC(Cl)=CC5

-20°C

Ice Packs

Small Compound