Microtubulin-IN-1 - CAS 3025180-14-4

Microtubulin-IN-1 (Compound 8g) is an inhibitor of microtubulin, targeting the colchicine-binding site to disrupt tubulin integrity and induce upregulation of p53 protein expression. It exhibits antiproliferative activity across various cancer cell lines, including NCI-H460, BxPC-3, and HT-29, with IC50 values of 2.4, 1.6, and 2.07 nM, respectively. Additionally, Microtubulin-IN-1 induces cell cycle arrest at the G2/M phase and apoptosis in NCI-H460 cells.

Apoptosis, MDM-2/p53, Microtubule Associated

Cytoskeletal Signaling, Apoptosis

3025162

C25H21FN4O3

444.458

C(\C=1N(C(C)C)C=CN1)=C\2/C(=O)N/C(=C\C3=CC(C(=O)C4=CC=C(F)C=C4)=CC=C3)/C(=O)N2

-20°C

Ice Packs

Small Compound