Migrastatin - CAS 314245-65-3

Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 μM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 μg/ml) and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay (IC50= 29 μM) .2It enhances cytotoxicity induced by vinblastine in vincristine-resistant P388/VCR cells.3

Others, Calcium Channel, AChR

Metabolism, Membrane transporter/Ion channel, Others, Neuroscience

314177

C27H39NO7

489.609

[H][C@@]1(OC(=O)\C=C/CC\C=C/[C@H](OC)[C@@H](O)[C@H](C)\C=C1/C)[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1 |c:5,9,t:18|

-20°C

Ice Packs

Small Compound