Miro1 Reducer - CAS 2624336-91-8

Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1) . Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM) . Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

Others

Others

2624237

C20H17FN7OCl

425.85

Cl.O=C(NC1=CC=C(C=C1)NC2=NC=NC(=C2)N3C=NC=C3)NC=4C=CC=C(F)C4

-20°C

Ice Packs

Small Compound