Mitapivat hydrochloride - CAS 2559738-69-9

Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R) . It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.

PKM

Metabolism

2559660

C24H27ClN4O3S

487.014

Cl.O=C(C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC3=CC=CN=C32)N4CCN(CC4)CC5CC5

-20°C

Ice Packs

Small Compound