Mitoxantrone - CAS 65271-80-9

Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.

Apoptosis, PKC, Endogenous Metabolite, Virus Protease, Topoisomerase

Cytoskeletal Signaling, DNA Damage/DNA Repair, Apoptosis, Chromatin/Epigenetic, Metabolism, Microbiology/Virology

65182

0.9874

C22H28N4O6

444.48

OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

-20°C

Ice Packs

Small Compound