MJ04 - CAS 2099014-23-8

MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg) .

EGFR, JAK, PI3K, GSK-3, IGF-1R

PI3K/Akt/mTOR signaling, Angiogenesis, Stem Cells, JAK/STAT signaling, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors

2099014-23-8

C20H16FN5

345.37

FC=1C=CC(=CC1)C2=CN=C3NC=C(C=4N=C(N=CC4)NC5CC5)C3=C2

-20°C

Ice Packs

Small Compound