MK-0731 - CAS 845256-65-7

MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in tumor cells that overexpress KSP.

Others, Apoptosis, Kinesin, Lipoxygenase

Cytoskeletal Signaling, Metabolism, Apoptosis, Others

845184

C25H28F3N3O2

459.5

C(O)[C@@]1(N(C(N(C)[C@@H]2[C@H](F)CN(C)CC2)=O)CC(=C1)C3=C(F)C=CC(F)=C3)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound