MK-2206 free base - CAS 1032349-93-1

MK-2206 free base is a potent, selective, and orally administered allosteric Akt inhibitor with IC50 values of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. It demonstrates sensitivity in various breast cancer cell lines, including those with PIK3CA mutations and PTEN loss, indicating its potential for anticancer activities [1] [2].

Akt, Apoptosis, Autophagy

PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Autophagy, Apoptosis

1032349-93-1

C25H21N5O

407.47

O=C1NN=C2C=3C=C(C=4C=CC=CC4)C(=NC3C=CN12)C=5C=CC(=CC5)C6(N)CCC6

-20°C

Ice Packs

Small Compound