MKA031 - CAS 2951012-00-1

MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF) with an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impedes MIF nuclear translocation, and mitigates N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) -induced cell death. MKA031 is applicable in research on chronic hepatitis C virus infection [1].

MIF, Others

Others, Immunology/Inflammation

2951012-00-1

C21H17N5O2S

403.46

O=C(NCC=1SC=CC1)C=2N=NN(C2)C3=CC=C(C=C3)C(=O)NC=4C=CC=CC4

-20°C

Ice Packs

Small Compound