ML-323 - CAS 1572414-83-5

ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM) and monoubiquitinated PCNA (Ub-PCNA) (IC50: 820 nM) as substrates, respectively.

DUB

Ubiquitination, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

1572326

0.9996

C23H24N6

384.48

CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-n2ccnn2)n1

-20°C

Ice Packs

Small Compound