MM-102 - CAS 1417329-24-8

MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay. MM-102 can also specifically inhibit cell growth and induce apoptosis in leukemia cells carrying MLL1 fusion protein.

TNF, Interleukin, Histone Methyltransferase, NF-κB, Apoptosis

Chromatin/Epigenetic, NF-κB, Immunology/Inflammation, Apoptosis

1417297

0.9999

C35H49F2N7O4

669.8

C(NC(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)(=O)C3(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(=N)N)=O)CCCC3

-20°C

Ice Packs

Small Compound