MM 54 - CAS 1313027-43-8

Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM) . Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.

Apelin receptor

GPCR/G Protein

1313027-43-8

C70H121N29O15S4

1737.15

O=C1N2[C@@](CCC2)(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CSSC[C@H](NC([C@H](CC3=CN=CN3)NC([C@@H](NC(=O)[C@H]4NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]5(N(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CSSC4)CCC5)[H])CCCCN)=O)=O)C(=O)N[C@H]1CCCNC(=N)N)[H]

-20°C

Ice Packs

Peptide