MMP-9 Inhibitor I - CAS 206549-55-5

MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively) . It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM) . MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.

MMP, Others

Proteases/Proteasome, Others

206489

C27H33N3O5S

511.63

N(S(=O)(=O)C1=CC=C(OC)C=C1)(CC2=CC=CC=C2)C3=C(C(NO)=O)C=C(CN(CC)CC)C=C3C

-20°C

Ice Packs

Small Compound