MMRi6 - CAS 709009-15-4

MMRi6 is an inhibitor of the Mdm2-MdmX RING domain, capable of disrupting Mdm2-MdmX RING-RING interactions in vitro. It inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated polyubiquitination of p53 without affecting NEDD4-1 autoubiquitination. In wt-p53 Emu-myc lymphoma cells, MMRi6 induces p53 stabilization and accumulation, as well as PARP cleavage. It inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells, with IC50 values of approximately 0.5 μM and 3 μM, respectively. MMRi6 is applicable in leukemia/lymphoma research.

PARP, MDM-2/p53

DNA Damage/DNA Repair, Apoptosis, Chromatin/Epigenetic

708990

C21H15Cl2N3O

396.27

ClC1=CC=CC(=C1)C(NC2=NC=CC=C2)C3=CC(Cl)=C4C=CC=NC4=C3O

-20°C

Ice Packs

Small Compound