MMRi62 - CAS 352693-80-2

MMRi62 (7-[ (2,3-dichlorophenyl) - (pyridin-2-ylamino) methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53) . MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1) . MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.

Apoptosis, Ferroptosis, Autophagy, MDM-2/p53, Ras, Kras

Apoptosis, Autophagy, MAPK

352611

0.9987

C21H15Cl2N3O

396.27

Oc1c(ccc2cccnc12)C(Nc1ccccn1)c1cccc(Cl)c1Cl

-20°C

Ice Packs

Small Compound