MMs02943764 - CAS 708287-29-0

MMs02943764, a derivative of 1,2,4-triazole, exhibits anticancer activity. This compound demonstrates significant antiproliferative effects across various cancer cell lines. Its structural analog, PAC, shows notable cytotoxicity towards the leukemia cell line K562 (IC50=35.264 μM), functioning by inhibiting Mdm2 and Pirh2 to reduce degradation of p53 and consequently inducing cell cycle arrest in K562 cells.

MDM-2/p53

Apoptosis

708258

C24H25BrF2N4O2S

551.45

O=C(NC=1C(F)=CC(F)=CC1Br)CSC2=NN=C(N2CC=C)COC3=CC(=CC=C3C(C)C)C

-20°C

Ice Packs

Small Compound