Modzatinib - CAS 2411407-25-3

Modzatinib (ITKkinase-IN-1) (compound I) is an inhibitor targeting ITK kinase with an IC50 of 8 nM in Jurkat cells, useful for researching inflammatory diseases. In hPBMC cells, it inhibits JAK3 with an IC50 of 23 nM (based on IL-2/pSTAT5 levels) and shows no inhibitory effect on JAK2.

JAK, Tyrosine Kinases

Chromatin/Epigenetic, Angiogenesis, JAK/STAT signaling, Stem Cells, Tyrosine Kinase/Adaptors

2411379

C18H21F2N5O

361.39

N(C1=C2C(=CNC2=NC=N1)[C@@H]3C(F)(F)C3)[C@H]4CN(C(C=C)=O)[C@@H](C)CC4

-20°C

Ice Packs

Small Compound