Moexipril-d5 - CAS 1356929-49-1

Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 μM for the rabbit enzyme) . It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 μM for PDE4B2, PDE4A5 and PDE4D5, respectively) . Moexipril (0.1-30 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.1 It also reduces infarct volume in a rat model of focal cerebral ischemia when used at a concentration of 0.01 mg/kg.

Apoptosis, Angiotensin-converting Enzyme (ACE)

Metabolism, Apoptosis

1356879

C27H29D5N2O7

503.6

C([C@@H](N[C@@H](CCC1=C(C(=C(C(=C1[2H])[2H])[2H])[2H])[2H])C(OCC)=O)C)(=O)N2CC=3C(C[C@H]2C(O)=O)=CC(OC)=C(OC)C3

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