MOMA-341 - CAS 3078276-74-8

MOMA-341 is a selective, ATP-competitive WRN allosteric inhibitor that binds to the cysteine 727 site of WRN. It induces DNA damage, cell death, and tumor regression in dMMR/MSI-H mouse models and can be used to study advanced and metastatic solid tumors.

DNA/RNA Synthesis

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

3078194

C28H26F4N6O3

570.54

C(=O)(N1[C@@]2(C3=C(N(N=C3CCN(C(C=C)=O)C2)C4=C(O)C=C(C=C4)C5CC5)CC1)[H])C=6C(N)=C(F)C(C(F)(F)F)=NC6

-20°C

Ice Packs

Small Compound