Momelotinib - CAS 1056634-68-4

Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells.

JAK, Autophagy, Apoptosis

JAK/STAT signaling, Chromatin/Epigenetic, Stem Cells, Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors, Autophagy

1056562

0.9956

C23H22N6O2

414.46

O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1

-20°C

Ice Packs

Small Compound