Mono (2-ethyl-5-hydroxyhexyl) terephthalate - CAS 1684398-38-6

Mono (2-ethyl-5-hydroxyhexyl) terephthalate (MEHHTP) is a hydroxy metabolite of Di-2-ethylhexyl terephthalate (DEHTP) and acts as an agonist of the liver X receptor α (LXRα) with a binding energy of -7.41 kcal/mol. MEHHTP upregulates downstream targets of LXRα, including SREBP-1c and FASN, enhancing lipogenic enzyme activity and increasing triglyceride (TG) levels in hepatocytes. This compound shows potential for research in non-alcoholic fatty liver disease (NAFLD) .

Drug Metabolite

Metabolism

1684398-38-6

C16H22O5

294.34

O=C(O)C1=CC=C(C=C1)C(=O)OCC(CC)CCC(O)C

-20°C

Ice Packs

Inhibitors & Agonists