Monoamine Oxidase B inhibitor 5 - CAS 2969160-15-2

Monoamine OxidaseB inhibitor 5 (Compound 16d) is a reversible and selective inhibitor of monoamine oxidase B (hMAO-B), with an IC50 value of 67.3 nM and a Ki of 82.5 nM. It exhibits favorable pharmacokinetic properties and low toxicity in rat models. Additionally, this compound alleviates motor impairments in a Parkinson's mouse model induced by MPTP, and it is characterized by its ability to penetrate the blood-brain barrier (BBB) .

Monoamine Oxidase

Neuroscience

2969160-15-2

C16H14FN3O2

299.3

O=C(N)CC1=NC=2C=CC(OCC3=CC=C(F)C=C3)=CC2N1

-20°C

Ice Packs

Small Compound