MORF-627 - CAS 2412688-16-3

MORF-627 is an orally active selective inhibitor of integrin αvβ6 (integrinαvβ6), with an IC50 of 9.2 nM as measured in a human serum ligand binding assay. It effectively inhibits αvβ6-mediated activation of TGF-β1 with an IC50 of 2.63 nM and suppresses SMAD2/3 phosphorylation, showing an IC50 of 8.3 nM. Additionally, MORF-627 ameliorates bleomycin-induced pulmonary fibrosis in mice.

Integrin, TGF-beta/Smad

Stem Cells, Cytoskeletal Signaling

2412669

C31H40FN3O4

537.67

[C@@H](C(O)=O)(C1=C([C@@H]2CCC3(CC3)CO2)C=CC(F)=C1)N4C[C@H](OCCCCC=5NC=6C(=CC5)CCCN6)CC4

-20°C

Ice Packs

Small Compound