MP1202 - CAS 2578974-82-8

MP1202 is a dual agonist for MOR and KOR, with EC50 values of 0.32 μM for mMOR-1 and 0.13 μM for mKOR-1. It exhibits functional selectivity by reducing β-arrestin1/2 recruitment in hMOR and hKOR while significantly activating G protein and Gα subtypes. In opioid receptor subtype knockout mouse models, MP1202 demonstrates potent antinociceptive effects without typical opioid side effects, albeit it induces conditioned place preference and aversion behaviors, indicating potential for analgesic research.

Opioid Receptor, Arrestin

Endocrinology/Hormones, GPCR/G Protein, Neuroscience

2578884

C27H29IN2O3

556.44

N(C(=O)C1=CC(I)=CC=C1)[C@H]2[C@]3([C@]45C=6C(O3)=C(O)C=CC6C[C@]([C@@]4(CC2)[H])(N(CC7CC7)CC5)[H])[H]

-20°C

Ice Packs

Small Compound