MPP+ iodide - CAS 36913-39-0

MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

Autophagy, Mitochondrial Metabolism

Autophagy, Metabolism

36874

0.9996

C12H12IN

297.13

[I-].C=1C=CC(=CC1)C=2C=C[N+](=CC2)C

-20°C

Ice Packs

Small Compound