MPT0B214 - CAS 1215208-65-3

MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of the mitotic marker MPM-2. Furthermore, the compound induced apoptotic cell death through mitochondria/caspase 9-dependent pathway. Notably, several KB-derived multidrug-resistant cancer cell lines were also sensitive to MPT0B214 treatment. (PLoS One. 2013;8 (3) :e58953) .

Others, Microtubule Associated, Mitochondrial Metabolism, Apoptosis, Caspase

Others, Proteases/Proteasome, Metabolism, Apoptosis, Cytoskeletal Signaling

1215140

C20H20N2O5

368.38

NC=1C2=C(N=C(C(=O)C3=CC(OC)=C(OC)C(OC)=C3)C=C2)C=CC1OC

-20°C

Ice Packs

Small Compound