MPT0G211 mesylate - CAS 2151854-33-8

MPT0G211 mesylate is a powerful and selective HDAC6 inhibitor (IC50 = 0.291 nM), with high oral bioavailability. It exhibits remarkable selectivity for HDAC6 over other HDAC isoforms (>1000-fold selectivity) . Additionally, MPT0G211 mesylate can effectively cross the blood-brain barrier. In preclinical studies using an Alzheimer's disease model, MPT0G211 mesylate has shown promising results in reducing tau phosphorylation and cognitive deficits. Furthermore, this compound exhibits anti-metastatic and neuroprotective effects, making it a potential candidate for anticancer interventions. [1] [2] [3].

Others, HDAC

Others, DNA Damage/DNA Repair, Chromatin/Epigenetic

2151813

C18H19N3O5S

389.43

CS(O)(=O)=O.ONC(=O)c1ccc(CNc2cccc3cccnc23)cc1

-20°C

Ice Packs

Small Compound