MrgprX2-IN-2 - CAS 2792205-87-7

MrgprX2-IN-2 (Compound example 12) is a selective antagonist of the Mas-related G protein-coupled receptor X2 (MRGPRX2) . It works by inhibiting MRGPRX2-mediated mast cell degranulation and the release of inflammatory mediators, thus blocking non-IgE-dependent immune responses. MrgprX2-IN-2 shows potential for research in the areas of pseudo-allergic reactions, chronic pruritus, and inflammatory diseases.

MRGPR

GPCR/G Protein

2792111

C20H19ClF6N6O

508.85

N(C=1N2C(=NC(C(F)(F)F)=C2)C=CC1)[C@H]3CC[C@@H](NC(=O)C4=CN(CC(F)(F)F)N=C4Cl)CC3

-20°C

Ice Packs

Small Compound