Mrgx2 antagonist-3 - CAS 2641397-91-1

Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.

MRGPR

GPCR/G Protein

2641305

C15H15F2N3O

291.3

O=C1C(=C(N=C2NC3=CC(F)=C(F)C=C3N12)C(C)C)CC

-20°C

Ice Packs

Small Compound