MRS4719 - CAS 2840581-32-8

MRS4719, a potent P2X4 receptor antagonist, exhibits a half-maximal inhibitory concentration (IC50) of 0.503 μM for the human P2X4 receptor. Demonstrating both neuroprotective and neuro-rehabilitative effects, it can decrease infarct volume and brain atrophy in an ischemic stroke model. Additionally, MRS4719 mitigates ATP-induced calcium influx in primary human monocyte-derived macrophages, making it a valuable tool for researching ischemic stroke.

Others, P2X Receptor

Others, Membrane transporter/Ion channel, Neuroscience

2840541

C26H13N5O3S.C6H15N

504.6

O=C1NC=2C=3C=CC=CC3C=CC2N(C4=CC=NC(=C4)C5=NOC(=S)N5)C(=O)C1.N(CC)(CC)CC

-20°C

Ice Packs

Small Compound