MRS4833 - CAS 2801627-78-9

MRS4833 (compound 15) is an orally active, potent, competitive antagonist of P2Y14R, exhibiting IC50 values of 5.92 nM for hP2Y14R and 4.8 nM for mP2Y14R. It reduces airway eosinophilia in protease-mediated asthma models and reverses chronic neuropathic pain in mouse CCI models.

P2Y Receptor

GPCR/G Protein, Neuroscience

2801540

C30H24F3NO3

503.51

O[C@]1([C@@]2(C[C@]1(CNC2)[H])[H])C3=CC=C(C=C3)C=4C5=C(C=C(C=C5)C6=CC=C(C(F)(F)F)C=C6)C=C(C(O)=O)C4

-20°C

Ice Packs

Small Compound