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MRT 67307 dihydrochloride - CAS 1781882-89-0

MRT 67307 dihydrochloride - CAS 1781882-89-0

MF-0094312-01

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Product Details

  • Bioactivity

    MRT 67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.

  • Target

    Autophagy, IκB/IKK, SIK

  • Related Pathways

    NF-κB, Autophagy, PI3K/Akt/mTOR signaling

  • CAS Number

    1781793

  • Purity

    0.9975

  • Molecular Formula

    C26H38Cl2N6O2

  • Molecular Weight

    537.53

  • SMILES

    O=C(C1CCC1)NCCCNC2=NC(NC3=CC=CC(CN4CCOCC4)=C3)=NC=C2C5CC5.Cl.Cl

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound