MRT199665 - CAS 1456858-57-3

MRT199665 is an effective and ATP-competitive, selective MARK/SIK/AMPK inhibitor (IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively) . MRT199665 suppresses the phosphorylation of SIK substrate CRTC3 at S370. MRT199665 induces apoptosis in MEF2C-activated human acute myeloid leukemia (AML) cells.

Others, Apoptosis, AMPK, SIK

Chromatin/Epigenetic, Apoptosis, PI3K/Akt/mTOR signaling, Others

1456798

C28H31N5O2

469.58

CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3cccc(CN4CCCC4)c3)ncc12

-20°C

Ice Packs

Small Compound