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Molfinity

MRTX-1257 - CAS 2206736-04-9

MRTX-1257 - CAS 2206736-04-9

MF-0033492-01

$53.35 USD
$53.35 USD
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Product Details

  • Bioactivity

    MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment.

  • Target

    Ras, Kras

  • Related Pathways

    GPCR/G Protein, MAPK

  • CAS Number

    2206736-04-9

  • Purity

    0.9907

  • Molecular Formula

    C33H39N7O2

  • Molecular Weight

    565.71

  • SMILES

    CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1cccc2cccc(C)c12

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound