MRTX849 acid - CAS 2561529-96-0

MRTX849 acid, a derivative of MRTX849, is employed in the synthesis of PROTAC LC-2. LC-2, a potent and pioneering PROTAC, exhibits the ability to efficiently degrade endogenous KRAS G12C with DC50 values ranging between 0.25 and 0.76 μM.

Others, Kras, Ras

MAPK, Others, GPCR/G Protein

2561433

C34H37ClFN7O4

662.16

OC(=O)CCN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12

-20°C

Ice Packs

Small Compound