MRTX849 ethoxypropanoic acid - CAS 2561529-98-2

MRTX849 ethoxypropanoic acid is a compound that contains a ligand for KRAS G12C and a PROTAC linker. It is commonly employed in the synthesis of PROTAC LC-2, which is a highly effective and innovative PROTAC. LC-2 has been proven to degrade endogenous KRAS G12C with remarkable potency, exhibiting DC50 values ranging from 0.25 to 0.76 μM.

Target Protein Ligand-Linker Conjugate, Others, Kras, Ras

MAPK, PROTAC, GPCR/G Protein, Others

2561429

C37H43ClFN7O5

720.24

OC(=O)CCOCCCN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12

-20°C

Ice Packs

PROTAC