MS-0022 - CAS 691392-89-9

MS-0022 is a SMO antagonist. MS-0022 showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of Suppressor of fused (SUFU) in the low μM range. MS-0022 reduced growth in the tumor cell lines PANC-1, SUIT-2, PC-3 and FEMX in vitro. MS-0022 is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal Gli1 levels in SUIT-2 xenografts in vivo.

Others, Smo, Hedgehog/Smoothened

GPCR/G Protein, Stem Cells, Others

691294

C21H16BrN3O

406.28

CC=1C2=NC(=CN2C=CC1)C3=CC=C(NC(=O)C4=C(Br)C=CC=C4)C=C3

-20°C

Ice Packs

Small Compound